Born into the Greengrass family, among the oldest, truly pure-blooded families in Britain, Astoria and her older sister, Daphne, were brought up in the ideals of Pure-blood supremacy.
Astoria's life was cut short by a curse placed upon her ancestor long before her time, resulting in her body becoming extremely frail.

Astoria attended Hogwarts School of Witchcraft and Wizardry. During the Battle of Hogwarts, she was evacuated for being too young. It is also unknown what house she was sorted into at Hogwarts.
The events of the Second Wizarding War during her teenage years made Astoria espouse a more tolerant life view, turning back on her family's blood purity ideals, although her experience through the war was less than that of what Draco Malfoy suffered.

At some point between 2000 and 2004/5, she eventually married Draco Malfoy.
Frail, and knowing she was not destined for old age due to her ancestor's blood borne curse, Astoria longed for a child so that Draco, after her inevitable death, would not be alone.
She was successful in producing a child, despite Draco telling her that he didn't care if the Malfoy family ended with him, but the pregnancy greatly weakened her and the family vanished into seclusion when Scorpius Hyperion Malfoy was born.
After Scorpius's birth, Astoria refused to teach her son the pure-blooded belief that Muggles were scum. Lucius and Narcissa Malfoy therefore found her a somewhat disappointing daughter-in-law; family gatherings were, as a result, often fraught with tension.

In the summer before Scorpius's third year at Hogwarts, Astoria died due to the toll of her family curse, leaving her son and husband heartbroken. Scorpius and Albus would later on attend her funeral.

Draco, having inherited a "true" Time-Turner from his father, was later urged to use it to go back in time to see Astoria, but he resisted, knowing the potential damage he could cause to reality.